Selected Publications

Google Scholar Profile for Richard W. Tsien

  • Mullins C, Fishell G, Tsien RW. Unifying Views of Autism Spectrum Disorders: A Consideration of Autoregulatory Feedback Loops. Neuron. 2016 Mar 16;89(6):1131–56. 
  • Cohen SM, Ma H, Kuchibhotla KV, Watson BO, Buzsáki G, Froemke RC, Tsien TW. Excitation-Transcription Coupling in Parvalbumin-Positive Interneurons Employs a Novel CaM Kinase-Dependent Pathway Distinct from Excitatory Neurons. Neuron. 2016 Apr 20;90(2):292–307. PMCID: PMC4866871
  • Li B, Tadross MR, Tsien RW. Sequential ionic and conformational signaling by calcium channels drives neuronal gene expression. Science. 2016 Feb 19;351(6275):863–7. 
  • Ma H, Groth RD, Cohen SM, Emery JF, Li B, Hoedt E, Tsien RW et al. γCaMKII shuttles Ca²⁺/CaM to the nucleus to trigger CREB phosphorylation and gene expression. Cell. 2014 Oct 9;159(2):281–94. PMCID: PMC4201038
  • Alabi AA, Tsien RW. (2013) Perspectives on kiss-and-run: role in exocytosis, endocytosis, and neurotransmission. Annu Rev Physiol. 75:393-422.
  • Owen SF, Tuncdemir SN, Bader PL, Tirko NN, Fishell G, Tsien RW. (2013) Oxytocin enhances hippocampal spike transmission by modulating fast-spiking interneurons. Nature. 500(7463):458-62.
  • Tadross MR, Tsien RW, Yue DT. (2013) Ca2+ channel nanodomains boost local Ca2+ amplitude. Proc Natl Acad Sci U S A. 110(39):15794-9.
  • Park H, Li Y, Tsien RW (2012). Influence of synaptic vesicle position on release probability and exocytotic fusion model. Science 335(6074):1362-6.
  • Wheeler DG, Groth RD, Ma H, Barrett CF, Owen SF, Safa P, Tsien RW (2012). CaV1 and CaV2 channels engage distinct modes of Ca2+ signaling to control CREB-dependent gene expression. Cell 149(5):1112-24.
  • Li Y, Tsien RW (2012). pHTomato, a red, genetically encoded indicator that enables multiplex interrogation of synaptic activity. Nat Neurosci 15(7):1047-53.
  • Alabi, A.A., Tsien, RW (2012). Synaptic Vesicle Pools and Dynamics. In: The Synapse, Sheng M, Sabatini BL, Südhof T, eds., Cold Spring Harbor Press, New York.
  • Ma H, Cohen S, Li B, Tsien RW. (2012) Exploring the dominant role of Cav1 channels in signalling to the nucleus. Biosci Rep. 33(1):97-101.
  • Groth RD, Lindskog M, Thiagarajan TC, Li L, Tsien RW (2011). Beta Ca2+/CaM-dependent kinase type II triggers upregulation of GluA1 to coordinate adaptation to synaptic inactivity in hippocampal neurons. Proc Natl Acad Sci USA 108(2):838-33.
  • Yoo AS, Sun AX, Li L, Shcheglovitov A, Portmann T, Li Y, Lee-Messer C, Dolmetsch RE, Tsien RW, Crabtree GR (2011). MicroRNA-mediated conversion of human fibroblasts to neurons. Nature 476(7359):228-31.
  • Bader, PL, Faizi M, Kim LH, Owen SF, Tadross MR, Alfa RW, Bett GCL, Tsien RW, Rasmusson RL, Shamloo M (2011). Mouse model of Timothy syndrome recapitulates triad of autistic traits. PNAS 108(37):15432-15437.
  • Mitra A, Mitra S, Tsien RW (2011). Heterogeneous reallocation of presynaptic efficacy in recurrent excitatory microcircuits adapting to inactivity. Nat Neurosci 15(2):250-7.
  • Lindskog M, Li L, Groth RD, Poburko D, Thiagarajan TC, Han X, Tsien RW (2010). Postsynaptic GluA1 enables acute retrograde enhancement of presynaptic function to coordinate the adaptation to synaptic inactivity. Proc Natl Acad Sci USA 107(50):21806-11.
  • Zhang Q, Li Y, Tsien RW (2009). The dynamic control of kiss-and-run and vesicular reuse probed with single nanoparticles. Science. 323(5920):1448-53. 
  • Kim J, Tsien RW (2008). Synapse-specific adaptations to inactivity in hippocampal circuits achieve homeostatic gain control while dampening network reverberation. Neuron 58(6):925-37.