Selected Publications

  • Kim J, Tsien RW (2008). Synapse-specific adaptations to inactivity in hippocampal circuits achieve homeostatic gain control while dampening network reverberation. Neuron 58(6):925-37.
  • Zhang Q, Li Y, Tsien RW (2009). The dynamic control of kiss-and-run and vesicular reuse probed with single nanoparticles. Science. 323(5920):1448-53. 
  • Lindskog M, Li L, Groth RD, Poburko D, Thiagarajan TC, Han X, Tsien RW (2010). Postsynaptic GluA1 enables acute retrograde enhancement of presynaptic function to coordinate the adaptation to synaptic inactivity. Proc Natl Acad Sci USA 107(50):21806-11.
  • Groth RD, Lindskog M, Thiagarajan TC, Li L, Tsien RW (2011). Beta Ca2+/CaM-dependent kinase type II triggers upregulation of GluA1 to coordinate adaptation to synaptic inactivity in hippocampal neurons. Proc Natl Acad Sci USA 108(2):838-33.
  • Yoo AS, Sun AX, Li L, Shcheglovitov A, Portmann T, Li Y, Lee-Messer C, Dolmetsch RE, Tsien RW, Crabtree GR (2011). MicroRNA-mediated conversion of human fibroblasts to neurons. Nature 476(7359):228-31.
  • Bader, PL, Faizi M, Kim LH, Owen SF, Tadross MR, Alfa RW, Bett GCL, Tsien RW, Rasmusson RL, Shamloo M (2011). Mouse model of Timothy syndrome recapitulates triad of autistic traits. PNAS 108(37):15432-15437.
  • Mitra A, Mitra S, Tsien RW (2011). Heterogeneous reallocation of presynaptic efficacy in recurrent excitatory microcircuits adapting to inactivity. Nat Neurosci 15(2):250-7.
  • Park H, Li Y, Tsien RW (2012). Influence of synaptic vesicle position on release probability and exocytotic fusion model. Science 335(6074):1362-6.
  • Wheeler DG, Groth RD, Ma H, Barrett CF, Owen SF, Safa P, Tsien RW (2012). CaV1 and CaV2 channels engage distinct modes of Ca2+ signaling to control CREB-dependent gene expression. Cell 149(5):1112-24.
  • Li Y, Tsien RW (2012). pHTomato, a red, genetically encoded indicator that enables multiplex interrogation of synaptic activity. Nat Neurosci 15(7):1047-53.
  • Alabi, A.A., Tsien, RW (2012). Synaptic Vesicle Pools and Dynamics. In: The Synapse, Sheng M, Sabatini BL, Südhof T, eds., Cold Spring Harbor Press, New York.
  • Ma H, Cohen S, Li B, Tsien RW. (2012) Exploring the dominant role of Cav1 channels in signalling to the nucleus. Biosci Rep. 33(1):97-101.
  • Alabi AA, Tsien RW. (2013) Perspectives on kiss-and-run: role in exocytosis, endocytosis, and neurotransmission. Annu Rev Physiol. 75:393-422.
  • Owen SF, Tuncdemir SN, Bader PL, Tirko NN, Fishell G, Tsien RW. (2013) Oxytocin enhances hippocampal spike transmission by modulating fast-spiking interneurons. Nature. 500(7463):458-62.
  • Tadross MR, Tsien RW, Yue DT. (2013) Ca2+ channel nanodomains boost local Ca2+ amplitude. Proc Natl Acad Sci U S A. 110(39):15794-9.
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