Publications

Publications

Publications

1. Leffler, Abba E; Kuryatov, Alexander; Zebroski, Henry A; Powell, Susan R; Filipenko, Petr; Hussein, Adel K; Gorson, Juliette; Heizmann, Anna; Lyskov, Sergey; Tsien, Richard W; Poget, Sebastien F; Nicke, Annette; Lindstrom, Jon; Rudy, Bernardo; Bonneau, Richard; Holford, Mande. "Discovery of peptide ligands through docking and virtual screening at nicotinic acetylcholine receptor homology models". Proceedings of the National Academy of Sciences of the United States of America (PNAS). 2017; 114: E8100 (#2688682)
2. Cohen, Samuel M; Ma, Huan; Kuchibhotla, Kishore V; Watson, Brendon O; Buzsaki, Gyorgy; Froemke, Robert C; Tsien, Richard W. "Excitation-Transcription Coupling in Parvalbumin-Positive Interneurons Employs a Novel CaM Kinase-Dependent Pathway Distinct from Excitatory Neurons". Neuron. 2016; 90: 292 (#2065982)
3. Li, Boxing; Tadross, Michael R; Tsien, Richard W. "Sequential ionic and conformational signaling by calcium channels drives neuronal gene expression". Science. 2016; 351: 863 (#1964842)
4. Mullins, Caitlin; Fishell, Gord; Tsien, Richard W. "Unifying Views of Autism Spectrum Disorders: A Consideration of Autoregulatory Feedback Loops". Neuron. 2016; 89: 1131 (#2032052)
5. Poo, Mu-Ming; Pignatelli, Michele; Ryan, Tomas J; Tonegawa, Susumu; Bonhoeffer, Tobias; Martin, Kelsey C; Rudenko, Andrii; Tsai, Li-Huei; Tsien, Richard W; Fishell, Gord; Mullins, Caitlin; Goncalves, J Tiago; Shtrahman, Matthew; Johnston, Stephen T; Gage, Fred H; Dan, Yang; Long, John; Buzsaki, Gyorgy; Stevens, Charles. "What is memory? The present state of the engram". BMC biology. 2016; 14: 40 (#2531292)
6. Adamantidis, Antoine; Arber, Silvia; Bains, Jaideep S; Bamberg, Ernst; Bonci, Antonello; Buzsaki, Gyorgy; Cardin, Jessica A; Costa, Rui M; Dan, Yang; Goda, Yukiko; Graybiel, Ann M; Hausser, Michael; Hegemann, Peter; Huguenard, John R; Insel, Thomas R; Janak, Patricia H; Johnston, Daniel; Josselyn, Sheena A; Koch, Christof; Kreitzer, Anatol C; Luscher, Christian; Malenka, Robert C; Miesenbock, Gero; Nagel, Georg; Roska, Botond; Schnitzer, Mark J; Shenoy, Krishna V; Soltesz, Ivan; Sternson, Scott M; Tsien, Richard W; Tsien, Roger Y; Turrigiano, Gina G; Tye, Kay M; Wilson, Rachel I. "Optogenetics: 10 years after ChR2 in neurons-views from the community". Nature neuroscience. 2015; 18: 1202 (#1742232)
7. Chenouard, N.; Tsien, R.W.. "An algorithm for piecewise-constant velocity estimation and application to particle trajectories in ". Proceedings (IEEE International Symposium on Biomedical Imaging : from nano to macro). 2015; 399 (#1749612)
8. Cohen, Samuel M; Li, Boxing; Tsien, Richard W; Ma, Huan. "Evolutionary and functional perspectives on signaling from neuronal surface to nucleus". Biochemical & biophysical research communications. 2015; 460: 88 (#1639732)
9. Cohen, Samuel M; Tsien, Richard W; Goff, Donald C; Halassa, Michael M. "The impact of NMDA receptor hypofunction on GABAergic neurons in the pathophysiology of schizophrenia". Schizophrenia research. 2015; 167: 98 (#1436132)
10. Ma, Huan; Li, Boxing; Tsien, Richard W. "Distinct roles of multiple isoforms of CaMKII in signaling to the nucleus". Biochimica & biophysica acta. 2015; 1853: 1953 (#1695912)
11. Ma, Huan; Sanchez, Sandrine; Kats, Ilona; Suutari, Benjamin; Tsien, Richard W. "CaMK2G, an Intellectual Disability Candidate Gene, Is Critical for Spatial Learning and Activity-dependent BDNF Synthesis in the Hippocampus.". Journal of general physiology. 2015; 146: 10A (#1873022)
12. Rosenberg, Evan C; Tsien, Richard W; Whalley, Benjamin J; Devinsky, Orrin. "Cannabinoids and Epilepsy". Neurotherapeutics. 2015; 12: 747 (#1732202)
13. Shen, Yiguo; Ge, Woo-Ping; Li, Yulong; Hirano, Arisa; Lee, Hsien-Yang; Rohlmann, Astrid; Missler, Markus; Tsien, Richard W; Jan, Lily Yeh; Fu, Ying-Hui; Ptacek, Louis J. "Protein mutated in paroxysmal dyskinesia interacts with the active zone protein RIM and suppresses synaptic vesicle exocytosis". Proceedings of the National Academy of Sciences of the United States of America (PNAS). 2015; 112: 2935 (#2035942)
14. Groth, Rachel D; Tirko, Natasha N; Tsien, Richard W. "CaV1.2 Calcium Channels: Just Cut Out to Be Regulated?". Neuron. 2014; 82: 939 (#1061872)
15. Karayannis, T; Au, E; Patel, J C; Kruglikov, I; Markx, S; Delorme, R; Heron, D; Salomon, D; Glessner, J; Restituito, S; Gordon, A; Rodriguez-Murillo, L; Roy, N C; Gogos, J A; Rudy, B; Rice, M E; Karayiorgou, M; Hakonarson, H; Keren, B; Huguet, G; Bourgeron, T; Hoeffer, C; Tsien, R W; Peles, E; Fishell, G. "Cntnap4 differentially contributes to GABAergic and dopaminergic synaptic transmission". Nature. 2014; 511: 236 (#1102842)
16. Ma, Huan; Groth, Rachel D; Cohen, Samuel M; Emery, John F; Li, Boxing; Hoedt, Esthelle; Zhang, Guoan; Neubert, Thomas A; Tsien, Richard W. "gammaCaMKII Shuttles Ca(2+)/CaM to the Nucleus to Trigger CREB Phosphorylation and Gene Expression". Cell. 2014; 159: 281 (#1300222)
17. Peng, Hanchuan; Tang, Jianyong; Xiao, Hang; Bria, Alessandro; Zhou, Jianlong; Butler, Victoria; Zhou, Zhi; Gonzalez-Bellido, Paloma T; Oh, Seung W; Chen, Jichao; Mitra, Ananya; Tsien, Richard W; Zeng, Hongkui; Ascoli, Giorgio A; Iannello, Giulio; Hawrylycz, Michael; Myers, Eugene; Long, Fuhui. "Virtual finger boosts three-dimensional imaging and microsurgery as well as terabyte volume image visualization and analysis". Nature communications. 2014; 5: 4342 (#2035682)
18. Alabi, AbdulRasheed A; Tsien, Richard W. "Perspectives on kiss-and-run: role in exocytosis, endocytosis, and neurotransmission". Annual review of physiology. 2013; 75: 393 (#306382)
19. Hong, Ingie; Kim, Jeongyeon; Kim, Jihye; Lee, Sukwon; Ko, Hyoung-Gon; Nader, Karim; Kaang, Bong-Kiun; Tsien, Richard W; Choi, Sukwoo. "AMPA receptor exchange underlies transient memory destabilization on retrieval". Proceedings of the National Academy of Sciences of the United States of America (PNAS). 2013; 110: 8218 (#421402)
20. Lee, Sukwon; Song, Beomjong; Kim, Jeongyeon; Park, Kyungjoon; Hong, Ingie; An, Bobae; Song, Sangho; Lee, Jiwon; Park, Sungmo; Kim, Jihye; Park, Dongeun; Lee, C Justin; Kim, Kyungjin; Shin, Ki Soon; Tsien, Richard W; Choi, Sukwoo. "GluA1 phosphorylation at serine 831 in the lateral amygdala is required for fear renewal". Nature neuroscience. 2013; 16: 1436 (#575922)
21. Liang, Liang; Li, Yulong; Potter, Christopher J; Yizhar, Ofer; Deisseroth, Karl; Tsien, Richard W; Luo, Liqun. "GABAergic projection neurons route selective olfactory inputs to specific higher-order neurons". Neuron. 2013; 79: 917 (#2035402)
22. Owen, Scott F; Tuncdemir, Sebnem N; Bader, Patrick L; Tirko, Natasha N; Fishell, Gord; Tsien, Richard W. "Oxytocin enhances hippocampal spike transmission by modulating fast-spiking interneurons". Nature. 2013; 500: 458 (#489582)
23. Tadross, Michael R; Tsien, Richard W; Yue, David T. "Ca2+ channel nanodomains boost local Ca2+ amplitude". Proceedings of the National Academy of Sciences of the United States of America (PNAS). 2013; 110: 15794 (#576102)
24. Alabi, AbdulRasheed A; Tsien, Richard W. "Synaptic vesicle pools and dynamics". Cold Spring Harbor perspectives in biology. 2012; 4: a013680 (#489592)
25. Kim, Jimok; Tsien, Richard W; Alger, Bradley E. "An improved test for detecting multiplicative homeostatic synaptic scaling". PLoS one. 2012; 7: e37364 (#489612)
26. Li, Yulong; Tsien, Richard W. "pHTomato, a red, genetically encoded indicator that enables multiplex interrogation of synaptic activity". Nature neuroscience. 2012; 15: 1047 (#173972)
27. Ma, Huan; Cohen, Samuel; Li, Boxing; Tsien, Richard W. "Exploring the dominant role of Cav1 channels in signalling to the nucleus". Bioscience reports. 2012; 33: 97 (#213912)
28. Park, Hyokeun; Li, Yulong; Tsien, Richard W. "Influence of synaptic vesicle position on release probability and exocytotic fusion mode". Science. 2012; 335: 1362 (#489602)
29. Wheeler, Damian G; Groth, Rachel D; Ma, Huan; Barrett, Curtis F; Owen, Scott F; Safa, Parsa; Tsien, Richard W. "Ca(V)1 and Ca(V)2 Channels Engage Distinct Modes of Ca(2+) Signaling to Control CREB-Dependent Gene Expression". Cell. 2012; 149: 1112 (#169566)
30. Bader, Patrick L; Faizi, Mehrdad; Kim, Leo H; Owen, Scott F; Tadross, Michael R; Alfa, Ronald W; Bett, Glenna C L; Tsien, Richard W; Rasmusson, Randall L; Shamloo, Mehrdad. "Mouse model of Timothy syndrome recapitulates triad of autistic traits". Proceedings of the National Academy of Sciences of the United States of America (PNAS). 2011; 108: 15432 (#138419)
31. Faizi, Mehrdad; Bader, Patrick L; Tun, Christine; Encarnacion, Angelo; Kleschevnikov, Alexander; Belichenko, Pavel; Saw, Nay; Priestley, Matthew; Tsien, Richard W; Mobley, William C; Shamloo, Mehrdad. "Comprehensive behavioral phenotyping of Ts65Dn mouse model of Down Syndrome: activation of beta1-adrenergic receptor by xamoterol as a potential cognitive enhancer". Neurobiology of disease. 2011; 43: 397 (#136716)
32. Groth, Rachel D; Lindskog, Maria; Thiagarajan, Tara C; Li, Li; Tsien, Richard W. "Beta Ca2+/CaM-dependent kinase type II triggers upregulation of GluA1 to coordinate adaptation to synaptic inactivity in hippocampal neurons". Proceedings of the National Academy of Sciences of the United States of America (PNAS). 2011; 108: 828 (#136719)
33. Ma, Huan; Groth, Rachel D; Wheeler, Damian G; Barrett, Curtis F; Tsien, Richard W. "Excitation-transcription coupling in sympathetic neurons and the molecular mechanism of its initiation". Neuroscience research. 2011; 70: 2 (#136718)
34. Mitra, Ananya; Mitra, Siddhartha S; Tsien, Richard W. "Heterogeneous reallocation of presynaptic efficacy in recurrent excitatory circuits adapting to inactivity". Nature neuroscience. 2011; 15: 250 (#489622)
35. Yoo, Andrew S; Sun, Alfred X; Li, Li; Shcheglovitov, Aleksandr; Portmann, Thomas; Li, Yulong; Lee-Messer, Chris; Dolmetsch, Ricardo E; Tsien, Richard W; Crabtree, Gerald R. "MicroRNA-mediated conversion of human fibroblasts to neurons". Nature. 2011; 476: 228 (#136717)
36. Bhat, Roopa; Axtell, Robert; Mitra, Ananya; Miranda, Melissa; Lock, Christopher; Tsien, Richard W; Steinman, Lawrence. "Inhibitory role for GABA in autoimmune inflammation". Proceedings of the National Academy of Sciences of the United States of America (PNAS). 2010; 107: 2580 (#136723)
37. Cao, Yu-Qing; Tsien, Richard W. "Different relationship of N- and P/Q-type Ca2+ channels to channel-interacting slots in controlling neurotransmission at cultured hippocampal synapses". Journal of neuroscience. 2010; 30: 4536 (#136722)
38. Lindskog, Maria; Li, Li; Groth, Rachel D; Poburko, Damon; Thiagarajan, Tara C; Han, Xue; Tsien, Richard W. "Postsynaptic GluA1 enables acute retrograde enhancement of presynaptic function to coordinate adaptation to synaptic inactivity". Proceedings of the National Academy of Sciences of the United States of America (PNAS). 2010; 107: 21806 (#136720)
39. Owen, Scott F; Tsien, Richard W. "Inhibitory neurons hear themselves during development". Neuron. 2010; 66: 164 (#136721)
40. Espinosa, J Sebastian; Wheeler, Damian G; Tsien, Richard W; Luo, Liqun. "Uncoupling dendrite growth and patterning: single-cell knockout analysis of NMDA receptor 2B". Neuron. 2009; 62: 205 (#136724)
41. Zhang, Qi; Li, Yulong; Tsien, Richard W. "The dynamic control of kiss-and-run and vesicular reuse probed with single nanoparticles". Science. 2009; 323: 1448 (#136725)
42. Barrett, Curtis F; Tsien, Richard W. "The Timothy syndrome mutation differentially affects voltage- and calcium-dependent inactivation of CaV1.2 L-type calcium channels". Proceedings of the National Academy of Sciences of the United States of America (PNAS). 2008; 105: 2157 (#136731)
43. Groth, Rachel D; Tsien, Richard W. "A role for retinoic acid in homeostatic plasticity". Neuron. 2008; 60: 192 (#136727)
44. Kim, Jimok; Tsien, Richard W. "Synapse-specific adaptations to inactivity in hippocampal circuits achieve homeostatic gain control while dampening network reverberation". Neuron. 2008; 58: 925 (#136729)
45. Liao, Yaping Joyce; Safa, Parsa; Chen, Yi-Ren; Sobel, Raymond A; Boyden, Edward S; Tsien, Richard W. "Anti-Ca2+ channel antibody attenuates Ca2+ currents and mimics cerebellar ataxia in vivo". Proceedings of the National Academy of Sciences of the United States of America (PNAS). 2008; 105: 2705 (#136730)
46. Watase, Kei; Barrett, Curtis F; Miyazaki, Taisuke; Ishiguro, Taro; Ishikawa, Kinya; Hu, Yuanxin; Unno, Toshinori; Sun, Yaling; Kasai, Sayumi; Watanabe, Masahiko; Gomez, Christopher M; Mizusawa, Hidehiro; Tsien, Richard W; Zoghbi, Huda Y. "Spinocerebellar ataxia type 6 knockin mice develop a progressive neuronal dysfunction with age-dependent accumulation of mutant CaV2.1 channels". Proceedings of the National Academy of Sciences of the United States of America (PNAS). 2008; 105: 11987 (#136728)
47. Wheeler, Damian G; Barrett, Curtis F; Groth, Rachel D; Safa, Parsa; Tsien, Richard W. "CaMKII locally encodes L-type channel activity to signal to nuclear CREB in excitation-transcription coupling". Journal of cell biology. 2008; 183: 849 (#136726)
48. Lisman, John E; Raghavachari, Sridhar; Tsien, Richard W. "The sequence of events that underlie quantal transmission at central glutamatergic synapses". Nature reviews. Neuroscience. 2007; 8: 597 (#136733)
49. Shcherbakova, Olga G; Hurt, Carl M; Xiang, Yang; Dell'Acqua, Mark L; Zhang, Qi; Tsien, Richard W; Kobilka, Brian K. "Organization of beta-adrenoceptor signaling compartments by sympathetic innervation of cardiac myocytes". Journal of cell biology. 2007; 176: 521 (#136735)
50. Thiagarajan, Tara C; Lindskog, Maria; Malgaroli, Antonio; Tsien, Richard W. "LTP and adaptation to inactivity: overlapping mechanisms and implications for metaplasticity". Neuropharmacology. 2007; 52: 156 (#136736)
51. Tour, Oded; Adams, Stephen R; Kerr, Rex A; Meijer, Rene M; Sejnowski, Terrence J; Tsien, Richard W; Tsien, Roger Y. "Calcium Green FlAsH as a genetically targeted small-molecule calcium indicator". Nature chemical biology. 2007; 3: 423 (#136734)
52. Tsien, Richard W. "A remembrance of Professor TP FENG". Sheng li xue bao : [Acta physiologica Sinica]. 2007; 59: 713 (#489632)
53. Zhang, Qi; Cao, Yu-Qing; Tsien, Richard W. "Quantum dots provide an optical signal specific to full collapse fusion of synaptic vesicles". Proceedings of the National Academy of Sciences of the United States of America (PNAS). 2007; 104: 17843 (#136732)
54. Boyden, Edward S; Katoh, Akira; Pyle, Jason L; Chatila, Talal A; Tsien, Richard W; Raymond, Jennifer L. "Selective engagement of plasticity mechanisms for motor memory storage". Neuron. 2006; 51: 823 (#136737)
55. Harata, Nobutoshi C; Aravanis, Alexander M; Tsien, Richard W. "Kiss-and-run and full-collapse fusion as modes of exo-endocytosis in neurosecretion". Journal of neurochemistry. 2006; 97: 1546 (#136739)
56. Harata, Nobutoshi C; Choi, Sukwoo; Pyle, Jason L; Aravanis, Alexander M; Tsien, Richard W. "Frequency-dependent kinetics and prevalence of kiss-and-run and reuse at hippocampal synapses studied with novel quenching methods". Neuron. 2006; 49: 243 (#136740)
57. Wheeler, Damian G; Barrett, Curtis F; Tsien, Richard W. "L-type calcium channel ligands block nicotine-induced signaling to CREB by inhibiting nicotinic receptors". Neuropharmacology. 2006; 51: 27 (#136738)
58. Barrett, Curtis F; Cao, Yu-Qing; Tsien, Richard W. "Gating deficiency in a familial hemiplegic migraine type 1 mutant P/Q-type calcium channel". Journal of biological chemistry. 2005; 280: 24064 (#136743)
59. Cao, Yu-Qing; Tsien, Richard W. "Effects of familial hemiplegic migraine type 1 mutations on neuronal P/Q-type Ca2+ channel activity and inhibitory synaptic transmission". Proceedings of the National Academy of Sciences of the United States of America (PNAS). 2005; 102: 2590 (#136744)
60. Hudmon, Andy; Schulman, Howard; Kim, James; Maltez, Janet M; Tsien, Richard W; Pitt, Geoffrey S. "CaMKII tethers to L-type Ca2+ channels, establishing a local and dedicated integrator of Ca2+ signals for facilitation". Journal of cell biology. 2005; 171: 537 (#136741)
61. Thiagarajan, Tara C; Lindskog, Maria; Tsien, Richard W. "Adaptation to synaptic inactivity in hippocampal neurons". Neuron. 2005; 47: 725 (#136742)
62. Cao, Yu-Qing; Piedras-Renteria, Erika S; Smith, Geoffrey B; Chen, Gong; Harata, Nobutoshi C; Tsien, Richard W. "Presynaptic Ca2+ channels compete for channel type-preferring slots in altered neurotransmission arising from Ca2+ channelopathy". Neuron. 2004; 43: 387 (#136745)
63. Chen, Gong; Harata, Nobutoshi C; Tsien, Richard W. "Paired-pulse depression of unitary quantal amplitude at single hippocampal synapses". Proceedings of the National Academy of Sciences of the United States of America (PNAS). 2004; 101: 1063 (#136747)
64. Pagani, R; Song, M; McEnery, M; Qin, N; Tsien, R W; Toro, L; Stefani, E; Uchitel, O D. "Differential expression of alpha 1 and beta subunits of voltage dependent Ca2+ channel at the neuromuscular junction of normal and P/Q Ca2+ channel knockout mouse". Neuroscience. 2004; 123: 75 (#136749)
65. Piedras-Renteria, Erika S; Pyle, Jason L; Diehn, Max; Glickfeld, Lindsey L; Harata, Nobutoshi C; Cao, Yuqing; Kavalali, Ege T; Brown, Patrick O; Tsien, Richard W. "Presynaptic homeostasis at CNS nerve terminals compensates for lack of a key Ca2+ entry pathway". Proceedings of the National Academy of Sciences of the United States of America (PNAS). 2004; 101: 3609 (#136746)
66. Smith, Stephen M; Bergsman, Jeremy B; Harata, Nobutoshi C; Scheller, Richard H; Tsien, Richard W. "Recordings from single neocortical nerve terminals reveal a nonselective cation channel activated by decreases in extracellular calcium". Neuron. 2004; 41: 243 (#136748)
67. Aravanis, A M; Pyle, J L; Harata, N C; Tsien, R W. "Imaging single synaptic vesicles undergoing repeated fusion events: kissing, running, and kissing again". Neuropharmacology. 2003; 45: 797 (#136750)
68. Aravanis, A M; Pyle, J L; Tsien, R W. "Single synaptic vesicles fusing transiently and successively without loss of identity". Nature. 2003; 423: 643 (#136751)
69. Choi, Sukwoo; Klingauf, Jurgen; Tsien, Richard W. "Fusion pore modulation as a presynaptic mechanism contributing to expression of long-term potentiation". Philosophical transactions of the Royal Society of London. Series B. Biological sciences. 2003; 358: 695 (#136753)
70. Deisseroth, Karl; Mermelstein, Paul G; Xia, Houhui; Tsien, Richard W. "Signaling from synapse to nucleus: the logic behind the mechanisms". Current opinion in neurobiology. 2003; 13: 354 (#136752)
71. Urbano, Francisco J; Piedras-Renteria, Erika S; Jun, Kisun; Shin, Hee-Sup; Uchitel, Osvaldo D; Tsien, Richard W. "Altered properties of quantal neurotransmitter release at endplates of mice lacking P/Q-type Ca2+ channels". Proceedings of the National Academy of Sciences of the United States of America (PNAS). 2003; 100: 3491 (#136754)
72. Cataldi, Mauro; Perez-Reyes, Edward; Tsien, Richard W. "Differences in apparent pore sizes of low and high voltage-activated Ca2+ channels". Journal of biological chemistry. 2002; 277: 45969 (#136756)
73. Deisseroth, Karl; Tsien, Richard W. "Dynamic multiphosphorylation passwords for activity-dependent gene expression". Neuron. 2002; 34: 179 (#136757)
74. Thiagarajan, Tara C; Piedras-Renteria, Erika S; Tsien, Richard W. "alpha- and betaCaMKII. Inverse regulation by neuronal activity and opposing effects on synaptic strength". Neuron. 2002; 36: 1103 (#136755)
75. Harata, N; Pyle, J L; Aravanis, A M; Mozhayeva, M; Kavalali, E T; Tsien, R W. "Limited numbers of recycling vesicles in small CNS nerve terminals: implications for neural signaling and vesicular cycling". Trends in neurosciences. 2001; 24: 637 (#136760)
76. Harata, N; Ryan, T A; Smith, S J; Buchanan, J; Tsien, R W. "Visualizing recycling synaptic vesicles in hippocampal neurons by FM 1-43 photoconversion". Proceedings of the National Academy of Sciences of the United States of America (PNAS). 2001; 98: 12748 (#136761)
77. Mermelstein, P G; Deisseroth, K; Dasgupta, N; Isaksen, A L; Tsien, R W. "Calmodulin priming: nuclear translocation of a calmodulin complex and the memory of prior neuronal activity". Proceedings of the National Academy of Sciences of the United States of America (PNAS). 2001; 98: 15342 (#136758)
78. Piedras-Renteria, E S; Watase, K; Harata, N; Zhuchenko, O; Zoghbi, H Y; Lee, C C; Tsien, R W. "Increased expression of alpha 1A Ca2+ channel currents arising from expanded trinucleotide repeats in spinocerebellar ataxia type 6". Journal of neuroscience. 2001; 21: 9185 (#136759)
79. Pitt, G S; Zuhlke, R D; Hudmon, A; Schulman, H; Reuter, H; Tsien, R W. "Molecular basis of calmodulin tethering and Ca2+-dependent inactivation of L-type Ca2+ channels". Journal of biological chemistry. 2001; 276: 30794 (#136762)
80. Wu, G Y; Deisseroth, K; Tsien, R W. "Activity-dependent CREB phosphorylation: convergence of a fast, sensitive calmodulin kinase pathway and a slow, less sensitive mitogen-activated protein kinase pathway". Proceedings of the National Academy of Sciences of the United States of America (PNAS). 2001; 98: 2808 (#136763)
81. Wu, G Y; Deisseroth, K; Tsien, R W. "Spaced stimuli stabilize MAPK pathway activation and its effects on dendritic morphology". Nature neuroscience. 2001; 4: 151 (#136764)
82. Bergsman, J B; Tsien, R W. "Syntaxin modulation of calcium channels in cortical synaptosomes as revealed by botulinum toxin C1". Journal of neuroscience. 2000; 20: 4368 (#136768)
83. Bezprozvanny, I; Zhong, P; Scheller, R H; Tsien, R W. "Molecular determinants of the functional interaction between syntaxin and N-type Ca2+ channel gating". Proceedings of the National Academy of Sciences of the United States of America (PNAS). 2000; 97: 13943 (#136765)
84. Choi, S; Klingauf, J; Tsien, R W. "Postfusional regulation of cleft glutamate concentration during LTP at 'silent synapses'". Nature neuroscience. 2000; 3: 330 (#136770)
85. Degtiar, V E; Scheller, R H; Tsien, R W. "Syntaxin modulation of slow inactivation of N-type calcium channels". Journal of neuroscience. 2000; 20: 4355 (#136769)
86. Ertel, E A; Campbell, K P; Harpold, M M; Hofmann, F; Mori, Y; Perez-Reyes, E; Schwartz, A; Snutch, T P; Tanabe, T; Birnbaumer, L; Tsien, R W; Catterall, W A. "Nomenclature of voltage-gated calcium channels". Neuron. 2000; 25: 533 (#136771)
87. Mermelstein, P G; Bito, H; Deisseroth, K; Tsien, R W. "Critical dependence of cAMP response element-binding protein phosphorylation on L-type calcium channels supports a selective response to EPSPs in preference to action potentials". Journal of neuroscience. 2000; 20: 266 (#136772)
88. Pyle, J L; Kavalali, E T; Piedras-Renteria, E S; Tsien, R W. "Rapid reuse of readily releasable pool vesicles at hippocampal synapses". Neuron. 2000; 28: 221 (#136766)
89. Zuhlke, R D; Pitt, G S; Tsien, R W; Reuter, H. "Ca2+-sensitive inactivation and facilitation of L-type Ca2+ channels both depend on specific amino acid residues in a consensus calmodulin-binding motif in the(alpha)1C subunit". Journal of biological chemistry. 2000; 275: 21121 (#136767)
90. Graef, I A; Mermelstein, P G; Stankunas, K; Neilson, J R; Deisseroth, K; Tsien, R W; Crabtree, G R. "L-type calcium channels and GSK-3 regulate the activity of NF-ATc4 in hippocampal neurons". Nature. 1999; 401: 703 (#136776)
91. Jun, K; Piedras-Renteria, E S; Smith, S M; Wheeler, D B; Lee, S B; Lee, T G; Chin, H; Adams, M E; Scheller, R H; Tsien, R W; Shin, H S. "Ablation of P/Q-type Ca(2+) channel currents, altered synaptic transmission, and progressive ataxia in mice lacking the alpha(1A)-subunit". Proceedings of the National Academy of Sciences of the United States of America (PNAS). 1999; 96: 15245 (#136773)
92. Kavalali, E T; Klingauf, J; Tsien, R W. "Activity-dependent regulation of synaptic clustering in a hippocampal culture system". Proceedings of the National Academy of Sciences of the United States of America (PNAS). 1999; 96: 12893 (#136775)
93. Kavalali, E T; Klingauf, J; Tsien, R W. "Properties of fast endocytosis at hippocampal synapses". Philosophical transactions of the Royal Society of London. Series B. Biological sciences. 1999; 354: 337 (#136779)
94. Liu, G; Choi, S; Tsien, R W. "Variability of neurotransmitter concentration and nonsaturation of postsynaptic AMPA receptors at synapses in hippocampal cultures and slices". Neuron. 1999; 22: 395 (#136780)
95. Pyle, J L; Kavalali, E T; Choi, S; Tsien, R W. "Visualization of synaptic activity in hippocampal slices with FM1-43 enabled by fluorescence quenching". Neuron. 1999; 24: 803 (#136774)
96. Smith, S M; Piedras-Rentera, E S; Namkung, Y; Shin, H S; Tsien, R W. "Neuronal voltage-activated calcium channels: on the roles of the alpha 1E and beta 3 subunits". Annals of the New York Academy of Sciences. 1999; 868: 175 (#136778)
97. Zuhlke, R D; Pitt, G S; Deisseroth, K; Tsien, R W; Reuter, H. "Calmodulin supports both inactivation and facilitation of L-type calcium channels". Nature. 1999; 399: 159 (#136777)
98. Deisseroth, K; Heist, E K; Tsien, R W. "Translocation of calmodulin to the nucleus supports CREB phosphorylation in hippocampal neurons". Nature. 1998; 392: 198 (#136785)
99. Klingauf, J; Kavalali, E T; Tsien, R W. "Kinetics and regulation of fast endocytosis at hippocampal synapses". Nature. 1998; 394: 581 (#136783)
100. Namkung, Y; Smith, S M; Lee, S B; Skrypnyk, N V; Kim, H L; Chin, H; Scheller, R H; Tsien, R W; Shin, H S. "Targeted disruption of the Ca2+ channel beta3 subunit reduces N- and L-type Ca2+ channel activity and alters the voltage-dependent activation of P/Q-type Ca2+ channels in neurons". Proceedings of the National Academy of Sciences of the United States of America (PNAS). 1998; 95: 12010 (#136782)
101. Newcomb, R; Szoke, B; Palma, A; Wang, G; Chen, X h; Hopkins, W; Cong, R; Miller, J; Urge, L; Tarczy-Hornoch, K; Loo, J A; Dooley, D J; Nadasdi, L; Tsien, R W; Lemos, J; Miljanich, G. "Selective peptide antagonist of the class E calcium channel from the venom of the tarantula Hysterocrates gigas". Biochemistry. 1998; 37: 15353 (#136781)
102. Piedras-Renteria, E S; Tsien, R W. "Antisense oligonucleotides against alpha1E reduce R-type calcium currents in cerebellar granule cells". Proceedings of the National Academy of Sciences of the United States of America (PNAS). 1998; 95: 7760 (#136784)
103. Tsien, R W. "Molecular physiology. Key clockwork component cloned". Nature. 1998; 391: (#136786)
104. Bito, H; Deisseroth, K; Tsien, R W. "Ca2+-dependent regulation in neuronal gene expression". Current opinion in neurobiology. 1997; 7: 419 (#136789)
105. Chen, X H; Tsien, R W. "Aspartate substitutions establish the concerted action of P-region glutamates in repeats I and III in forming the protonation site of L-type Ca2+ channels". Journal of biological chemistry. 1997; 272: 30002 (#136787)
106. Kavalali, E T; Zhuo, M; Bito, H; Tsien, R W. "Dendritic Ca2+ channels characterized by recordings from isolated hippocampal dendritic segments". Neuron. 1997; 18: 651 (#136791)
107. Randall, A D; Tsien, R W. "Contrasting biophysical and pharmacological properties of T-type and R-type calcium channels". Neuropharmacology. 1997; 36: 879 (#136788)
108. Stocker, J W; Nadasdi, L; Aldrich, R W; Tsien, R W. "Preferential interaction of omega-conotoxins with inactivated N-type Ca2+ channels". Journal of neuroscience. 1997; 17: 3002 (#136790)
109. Bito, H; Deisseroth, K; Tsien, R W. "CREB phosphorylation and dephosphorylation: a Ca(2+)- and stimulus duration-dependent switch for hippocampal gene expression". Cell. 1996; 87: 1203 (#136792)
110. Chen, X H; Bezprozvanny, I; Tsien, R W. "Molecular basis of proton block of L-type Ca2+ channels". Journal of general physiology. 1996; 108: 363 (#136793)
111. Deisseroth, K; Bito, H; Tsien, R W. "Signaling from synapse to nucleus: postsynaptic CREB phosphorylation during multiple forms of hippocampal synaptic plasticity". Neuron. 1996; 16: 89 (#136796)
112. Wheeler, D B; Randall, A; Tsien, R W. "Changes in action potential duration alter reliance of excitatory synaptic transmission on multiple types of Ca2+ channels in rat hippocampus". Journal of neuroscience. 1996; 16: 2226 (#136795)
113. Zhang, J F; Ellinor, P T; Aldrich, R W; Tsien, R W. "Multiple structural elements in voltage-dependent Ca2+ channels support their inhibition by G proteins". Neuron. 1996; 17: 991 (#136794)
114. Bezprozvanny, I; Scheller, R H; Tsien, R W. "Functional impact of syntaxin on gating of N-type and Q-type calcium channels". Nature. 1995; 378: 623 (#136797)
115. Bezprozvanny, I; Tsien, R W. "Voltage-dependent blockade of diverse types of voltage-gated Ca2+ channels expressed in Xenopus oocytes by the Ca2+ channel antagonist mibefradil (Ro 40-5967)". Molecular pharmacology. 1995; 48: 540 (#136801)
116. Deisseroth, K; Bito, H; Schulman, H; Tsien, R W. "Synaptic plasticity: A molecular mechanism for metaplasticity". Current biology. CB. 1995; 5: 1334 (#136798)
117. Ellinor, P T; Yang, J; Sather, W A; Zhang, J F; Tsien, R W. "Ca2+ channel selectivity at a single locus for high-affinity Ca2+ interactions". Neuron. 1995; 15: 1121 (#136799)
118. Liu, G; Tsien, R W. "Properties of synaptic transmission at single hippocampal synaptic boutons". Nature. 1995; 375: 404 (#136803)
119. Liu, G; Tsien, R W. "Synaptic transmission at single visualized hippocampal boutons". Neuropharmacology. 1995; 34: 1407 (#136800)
120. Malgaroli, A; Ting, A E; Wendland, B; Bergamaschi, A; Villa, A; Tsien, R W; Scheller, R H. "Presynaptic component of long-term potentiation visualized at individual hippocampal synapses". Science. 1995; 268: 1624 (#136802)
121. Randall, A; Tsien, R W. "Pharmacological dissection of multiple types of Ca2+ channel currents in rat cerebellar granule neurons". Journal of neuroscience. 1995; 15: 2995 (#136804)
122. Tsien, R W; Lipscombe, D; Madison, D; Bley, K; Fox, A. "Reflections on Ca(2+)-channel diversity, 1988-1994". Trends in neurosciences. 1995; 18: 52 (#136805)
123. Wheeler, D B; Randall, A; Sather, W A; Tsien, R W. "Neuronal calcium channels encoded by the alpha 1A subunit and their contribution to excitatory synaptic transmission in the CNS". Progress in brain research. 1995; 105: 65 (#136806)
124. Chiang, L W; Schweizer, F E; Tsien, R W; Schulman, H. "Nitric oxide synthase expression in single hippocampal neurons". Brain research. Molecular brain research. 1994; 27: 183 (#136811)
125. Ellinor, P T; Zhang, J F; Horne, W A; Tsien, R W. "Structural determinants of the blockade of N-type calcium channels by a peptide neurotoxin". Nature. 1994; 372: 272 (#136808)
126. Friel, D D; Tsien, R W. "An FCCP-sensitive Ca2+ store in bullfrog sympathetic neurons and its participation in stimulus-evoked changes in [Ca2+]i". Journal of neuroscience. 1994; 14: 4007 (#136812)
127. Sather, W A; Tanabe, T; Zhang, J F; Tsien, R W. "Biophysical and pharmacological characterization of a class A calcium channel". Annals of the New York Academy of Sciences. 1994; 747: 294 (#136807)
128. Sather, W A; Yang, J; Tsien, R W. "Structural basis of ion channel permeation and selectivity". Current opinion in neurobiology. 1994; 4: 313 (#136813)
129. Wendland, B; Schweizer, F E; Ryan, T A; Nakane, M; Murad, F; Scheller, R H; Tsien, R W. "Existence of nitric oxide synthase in rat hippocampal pyramidal cells". Proceedings of the National Academy of Sciences of the United States of America (PNAS). 1994; 91: 2151 (#136815)
130. Wheeler, D B; Randall, A; Tsien, R W. "Roles of N-type and Q-type Ca2+ channels in supporting hippocampal synaptic transmission". Science. 1994; 264: 107 (#136814)
131. Wheeler, D B; Sather, W A; Randall, A; Tsien, R W. "Distinctive properties of a neuronal calcium channel and its contribution to excitatory synaptic transmission in the central nervous system". Advances in second messenger & phosphoprotein research. 1994; 29: 155 (#136816)
132. Wheeler, D B; Tsien, R W; Randall, A. "Response". Science. 1994; 266: 830 (#136809)
133. Zhang, J F; Ellinor, P T; Aldrich, R W; Tsien, R W. "Molecular determinants of voltage-dependent inactivation in calcium channels". Nature. 1994; 372: 97 (#136810)
134. Delcour, A H; Lipscombe, D; Tsien, R W. "Multiple modes of N-type calcium channel activity distinguished by differences in gating kinetics". Journal of neuroscience. 1993; 13: 181 (#136825)
135. Delcour, A H; Tsien, R W. "Altered prevalence of gating modes in neurotransmitter inhibition of N-type calcium channels". Science. 1993; 259: 980 (#136823)
136. Ellinor, P T; Zhang, J F; Randall, A D; Zhou, M; Schwarz, T L; Tsien, R W; Horne, W A. "Functional expression of a rapidly inactivating neuronal calcium channel". Nature. 1993; 363: 455 (#136821)
137. Horne, W A; Ellinor, P T; Inman, I; Zhou, M; Tsien, R W; Schwarz, T L. "Molecular diversity of Ca2+ channel alpha 1 subunits from the marine ray Discopyge ommata". Proceedings of the National Academy of Sciences of the United States of America (PNAS). 1993; 90: 3787 (#136822)
138. Ryan, T A; Reuter, H; Wendland, B; Schweizer, F E; Tsien, R W; Smith, S J. "The kinetics of synaptic vesicle recycling measured at single presynaptic boutons". Neuron. 1993; 11: 713 (#136819)
139. Sather, W A; Tanabe, T; Zhang, J F; Mori, Y; Adams, M E; Tsien, R W. "Distinctive biophysical and pharmacological properties of class A (BI) calcium channel alpha 1 subunits". Neuron. 1993; 11: 291 (#136820)
140. Yang, J; Ellinor, P T; Sather, W A; Zhang, J F; Tsien, R W. "Molecular determinants of Ca2+ selectivity and ion permeation in L-type Ca2+ channels". Nature. 1993; 366: 158 (#136817)
141. Yang, J; Tsien, R W. "Enhancement of N- and L-type calcium channel currents by protein kinase C in frog sympathetic neurons". Neuron. 1993; 10: 127 (#136824)
142. Zhang, J F; Randall, A D; Ellinor, P T; Horne, W A; Sather, W A; Tanabe, T; Schwarz, T L; Tsien, R W. "Distinctive pharmacology and kinetics of cloned neuronal Ca2+ channels and their possible counterparts in mammalian CNS neurons". Neuropharmacology. 1993; 32: 1075 (#136818)
143. Friel, D D; Tsien, R W. "A caffeine- and ryanodine-sensitive Ca2+ store in bullfrog sympathetic neurones modulates effects of Ca2+ entry on [Ca2+]i". Journal of physiology. 1992; 450: 217 (#136828)
144. Friel, D D; Tsien, R W. "Phase-dependent contributions from Ca2+ entry and Ca2+ release to caffeine-induced [Ca2+]i oscillations in bullfrog sympathetic neurons". Neuron. 1992; 8: 1109 (#136826)
145. Malgaroli, A; Malinow, R; Schulman, H; Tsien, R W. "Persistent signalling and changes in presynaptic function in long-term potentiation". CIBA Foundation symposium. 1992; 164: 176 (#136829)
146. Malgaroli, A; Tsien, R W. "Glutamate-induced long-term potentiation of the frequency of miniature synaptic currents in cultured hippocampal neurons". Nature. 1992; 357: 134 (#136827)
147. Cline, H T; Tsien, R W. "Glutamate-induced increases in intracellular Ca2+ in cultured frog tectal cells mediated by direct activation of NMDA receptor channels". Neuron. 1991; 6: 259 (#136832)
148. Horne, W A; Hawrot, E; Tsien, R W. "omega-Conotoxin GVIA receptors of Discopyge electric organ. Characterization of omega-conotoxin binding to the nicotinic acetylcholine receptor". Journal of biological chemistry. 1991; 266: 13719 (#136831)
149. Malinow, R; Tsien, R W. "Long-term potentiation: postsynaptic activation of Ca(2+)-dependent protein kinases with subsequent presynaptic enhancement". Progress in brain research. 1991; 89: 271 (#136834)
150. Tsien, R W; Ellinor, P T; Horne, W A. "Molecular diversity of voltage-dependent Ca2+ channels". Trends in pharmacological science. 1991; 12: 349 (#136830)
151. Tsien, R W; Malinow, R. "Changes in presynaptic function during long-term potentiation". Annals of the New York Academy of Sciences. 1991; 635: 208 (#136833)
152. Bley, K R; Tsien, R W. "Inhibition of Ca2+ and K+ channels in sympathetic neurons by neuropeptides and other ganglionic transmitters". Neuron. 1990; 4: 379 (#136836)
153. Malinow, R; Tsien, R W. "Identifying and localizing protein kinases necessary for LTP". Advances in experimental medicine & biology. 1990; 268: 301 (#136837)
154. Malinow, R; Tsien, R W. "Presynaptic enhancement shown by whole-cell recordings of long-term potentiation in hippocampal slices". Nature. 1990; 346: 177 (#136835)
155. Tsien, R W; Malinow, R. "Long-term potentiation: presynaptic enhancement following postsynaptic activation of Ca(++)-dependent protein kinases". Cold Spring Harbor symposia on quantitative biology. 1990; 55: 147 (#136840)
156. Tsien, R W; Schulman, H; Malinow, R. "Peptide inhibitors of PKC and CaMK block induction but not expression of long-term potentiation". Advances in second messenger & phosphoprotein research. 1990; 24: 101 (#136838)
157. Tsien, R W; Tsien, R Y. "Calcium channels, stores, and oscillations". Annual review of cell biology. 1990; 6: 715 (#136839)
158. Friel, D D; Tsien, R W. "Voltage-gated calcium channels: direct observation of the anomalous mole fraction effect at the single-channel level". Proceedings of the National Academy of Sciences of the United States of America (PNAS). 1989; 86: 5207 (#136843)
159. Kongsamut, S; Lipscombe, D; Tsien, R W. "The N-type Ca channel in frog sympathetic neurons and its role in alpha-adrenergic modulation of transmitter release". Annals of the New York Academy of Sciences. 1989; 560: 312 (#136844)
160. Lipscombe, D; Kongsamut, S; Tsien, R W. "Alpha-adrenergic inhibition of sympathetic neurotransmitter release mediated by modulation of N-type calcium-channel gating". Nature. 1989; 340: 639 (#136842)
161. Malinow, R; Schulman, H; Tsien, R W. "Inhibition of postsynaptic PKC or CaMKII blocks induction but not expression of LTP". Science. 1989; 245: 862 (#136841)
162. Rosenberg, R L; Isaacson, J S; Tsien, R W. "Solubilization, partial purification, and properties of omega-conotoxin receptors associated with voltage-dependent calcium channels from rat brain synaptosomes". Annals of the New York Academy of Sciences. 1989; 560: 39 (#136845)
163. Benham, C D; Tsien, R W. "Noradrenaline modulation of calcium channels in single smooth muscle cells from rabbit ear artery". Journal of physiology. 1988; 404: 767 (#136847)
164. Hirning, L D; Fox, A P; McCleskey, E W; Olivera, B M; Thayer, S A; Miller, R J; Tsien, R W. "Dominant role of N-type Ca2+ channels in evoked release of norepinephrine from sympathetic neurons". Science. 1988; 239: 57 (#136853)
165. Lipscombe, D; Madison, D V; Poenie, M; Reuter, H; Tsien, R W; Tsien, R Y. "Imaging of cytosolic Ca2+ transients arising from Ca2+ stores and Ca2+ channels in sympathetic neurons". Neuron. 1988; 1: 355 (#136850)
166. Lipscombe, D; Madison, D V; Poenie, M; Reuter, H; Tsien, R Y; Tsien, R W. "Spatial distribution of calcium channels and cytosolic calcium transients in growth cones and cell bodies of sympathetic neurons". Proceedings of the National Academy of Sciences of the United States of America (PNAS). 1988; 85: 2398 (#136851)
167. Malinow, R; Madison, D V; Tsien, R W. "Persistent protein kinase activity underlying long-term potentiation". Nature. 1988; 335: 820 (#136846)
168. Miller, R J; Ewald, D A; Fox, A P; Hirning, L D; McCleskey, E W; Perney, T M; Sturek, M; Thayer, S A; Tsien, R W; Walker, M W. "The effect of calcium channel antagonists on peripheral neurones". Annals of the New York Academy of Sciences. 1988; 522: 269 (#136852)
169. Rosenberg, R L; Hess, P; Tsien, R W. "Cardiac calcium channels in planar lipid bilayers. L-type channels and calcium-permeable channels open at negative membrane potentials". Journal of general physiology. 1988; 92: 27 (#136849)
170. Tsien, R W; Lipscombe, D; Madison, D V; Bley, K R; Fox, A P. "Multiple types of neuronal calcium channels and their selective modulation". Trends in neurosciences. 1988; 11: 431 (#136848)
171. Benham, C D; Hess, P; Tsien, R W. "Two types of calcium channels in single smooth muscle cells from rabbit ear artery studied with whole-cell and single-channel recordings". Circulation research. 1987; 61: I10 (#136857)
172. Benham, C D; Tsien, R W. "A novel receptor-operated Ca2+-permeable channel activated by ATP in smooth muscle". Nature. 1987; 328: 275 (#136859)
173. Benham, C D; Tsien, R W. "Calcium-permeable channels in vascular smooth muscle: voltage-activated, receptor-operated, and leak channels". Society of General Physiologists series. 1987; 42: 45 (#136863)
174. Fox, A P; Nowycky, M C; Tsien, R W. "Kinetic and pharmacological properties distinguishing three types of calcium currents in chick sensory neurones". Journal of physiology. 1987; 394: 149 (#136856)
175. Fox, A P; Nowycky, M C; Tsien, R W. "Single-channel recordings of three types of calcium channels in chick sensory neurones". Journal of physiology. 1987; 394: 173 (#136855)
176. Lieberman, M; Hauschka, S D; Hall, Z W; Eisenberg, B R; Horn, R; Walsh, J V; Tsien, R W; Jones, A W; Walker, J L; Poenie, M. "Isolated muscle cells as a physiological model". American journal of physiology. 1987; 253: C349 (#136858)
177. McCleskey, E W; Fox, A P; Feldman, D H; Cruz, L J; Olivera, B M; Tsien, R W; Yoshikami, D. "Omega-conotoxin: direct and persistent blockade of specific types of calcium channels in neurons but not muscle". Proceedings of the National Academy of Sciences of the United States of America (PNAS). 1987; 84: 4327 (#136860)
178. Strong, J A; Fox, A P; Tsien, R W; Kaczmarek, L K. "Stimulation of protein kinase C recruits covert calcium channels in Aplysia bag cell neurons". Nature. 1987; 325: 714 (#136861)
179. Tsien, R W; Fox, A P; Hess, P; McCleskey, E W; Nilius, B; Nowycky, M C; Rosenberg, R L. "Multiple types of calcium channel in excitable cells". Society of General Physiologists series. 1987; 41: 167 (#136864)
180. Tsien, R W; Hess, P; McCleskey, E W; Rosenberg, R L. "Calcium channels: mechanisms of selectivity, permeation, and block". Annual review of biophysics & biophysical chemistry. 1987; 16: 265 (#136862)
181. Tsien, R W; Nilius, B. "Cardiac calcium currents at the level of single channels". Experientia. 1987; 43: 1169 (#136854)
182. Hess, P; Lansman, J B; Nilius, B; Tsien, R W. "Calcium channel types in cardiac myocytes: modulation by dihydropyridines and beta-adrenergic stimulation". Journal of cardiovascular pharmacology. 1986; 8 Suppl 9: S11 (#136871)
183. Hess, P; Lansman, J B; Tsien, R W. "Calcium channel selectivity for divalent and monovalent cations. Voltage and concentration dependence of single channel current in ventricular heart cells". Journal of general physiology. 1986; 88: 293 (#136867)
184. Lansman, J B; Hess, P; Tsien, R W. "Blockade of current through single calcium channels by Cd2+, Mg2+, and Ca2+. Voltage and concentration dependence of calcium entry into the pore". Journal of general physiology. 1986; 88: 321 (#136866)
185. McCleskey, E W; Fox, A P; Feldman, D; Tsien, R W. "Different types of calcium channels". Journal of experimental biology. 1986; 124: 177 (#136865)
186. Nilius, B; Hess, P; Lansman, J B; Tsien, R W. "A novel type of cardiac calcium channel in ventricular cells". Biomedica biochimica acta. 1986; 45: S167 (#136870)
187. Rosenberg, R L; Hess, P; Reeves, J P; Smilowitz, H; Tsien, R W. "Calcium channels in planar lipid bilayers: insights into mechanisms of ion permeation and gating". Science. 1986; 231: 1564 (#136869)
188. Tsien, R W; Bean, B P; Hess, P; Lansman, J B; Nilius, B; Nowycky, M C. "Mechanisms of calcium channel modulation by beta-adrenergic agents and dihydropyridine calcium agonists". Journal of molecular & cellular cardiology. 1986; 18: 691 (#136868)
189. Lee, K S; Marban, E; Tsien, R W. "Inactivation of calcium channels in mammalian heart cells: joint dependence on membrane potential and intracellular calcium". Journal of physiology. 1985; 364: 395 (#136874)
190. Nilius, B; Hess, P; Lansman, J B; Tsien, R W. "A novel type of cardiac calcium channel in ventricular cells". Nature. 1985; 316: 443 (#136872)
191. Nowycky, M C; Fox, A P; Tsien, R W. "Long-opening mode of gating of neuronal calcium channels and its promotion by the dihydropyridine calcium agonist Bay K 8644". Proceedings of the National Academy of Sciences of the United States of America (PNAS). 1985; 82: 2178 (#136875)
192. Nowycky, M C; Fox, A P; Tsien, R W. "Three types of neuronal calcium channel with different calcium agonist sensitivity". Nature. 1985; 316: 440 (#136873)
193. Bean, B P; Nowycky, M C; Tsien, R W. "Beta-adrenergic modulation of calcium channels in frog ventricular heart cells". Nature. 1984; 307: 371 (#136880)
194. Cohen, C J; Bean, B P; Tsien, R W. "Maximal upstroke velocity as an index of available sodium conductance. Comparison of maximal upstroke velocity and voltage clamp measurements of sodium current in rabbit Purkinje fibers". Circulation research. 1984; 54: 636 (#136878)
195. Hess, P; Lansman, J B; Tsien, R W. "Different modes of Ca channel gating behaviour favoured by dihydropyridine Ca agonists and antagonists". Nature. 1984; 311: 538 (#136876)
196. Hess, P; Tsien, R W. "Mechanism of ion permeation through calcium channels". Nature. 1984; 309: 453 (#136879)
197. Lee, K S; Tsien, R W. "High selectivity of calcium channels in single dialysed heart cells of the guinea-pig". Journal of physiology. 1984; 354: 253 (#136877)
198. Bean, B P; Cohen, C J; Tsien, R W. "Lidocaine block of cardiac sodium channels". Journal of general physiology. 1983; 81: 613 (#136881)
199. Lee, K S; Tsien, R W. "Mechanism of calcium channel blockade by verapamil, D600, diltiazem and nitrendipine in single dialysed heart cells". Nature. 1983; 302: 790 (#136882)
200. Tsien, R W. "Calcium channels in excitable cell membranes". Annual review of physiology. 1983; 45: 341 (#136883)
201. Tsien, R W; Bean, B P; Hess, P; Nowycky, M. "Calcium channels: mechanisms of beta-adrenergic modulation and ion permeation". Cold Spring Harbor symposia on quantitative biology. 1983; 48 Pt 1: 201 (#136884)
202. Kass, R S; Tsien, R W. "Fluctuations in membrane current driven by intracellular calcium in cardiac Purkinje fibers". Biophysical journal. 1982; 38: 259 (#136889)
203. Lee, K S; Tsien, R W. "Reversal of current through calcium channels in dialysed single heart cells". Nature. 1982; 297: 498 (#136888)
204. Marban, E; Tsien, R W. "Effects of nystatin-mediated intracellular ion substitution on membrane currents in calf purkinje fibres". Journal of physiology. 1982; 329: 569 (#136886)
205. Marban, E; Tsien, R W. "Enhancement of calcium current during digitalis inotropy in mammalian heart: positive feed-back regulation by intracellular calcium?". Journal of physiology. 1982; 329: 589 (#136885)
206. Reuter, H; Stevens, C F; Tsien, R W; Yellen, G. "Properties of single calcium channels in cardiac cell culture". Nature. 1982; 297: 501 (#136887)
207. Cohen, C J; Bean, B P; Colatsky, T J; Tsien, R W. "Tetrodotoxin block of sodium channels in rabbit Purkinje fibers. Interactions between toxin binding and channel gating". Journal of general physiology. 1981; 78: 383 (#136890)
208. Marban, E; Rink, T J; Tsien, R W; Tsien, R Y. "Free calcium in heart muscle at rest and during contraction measured with Ca2+ -sensitive microelectrodes". Nature. 1980; 286: 845 (#136891)
209. Siegelbaum, S A; Tsien, R W. "Calcium-activated transient outward current in calf cardiac Purkinje fibres". Journal of physiology. 1980; 299: 485 (#136892)
210. Cohen, C J; Colatsky, T J; Tsien, R W. "Tetrodotoxin block of cardiac sodium channels during repetitive or steady depolarizations in the rabbit [proceedings]". Journal of physiology. 1979; 296: 70P (#136893)
211. Colatsky, J J; Tsien, R W. "Sodium channels in rabbit cardiac Purkinje fibres". Nature. 1979; 278: 265 (#136898)
212. Colatsky, T J; Tsien, R W. "Electrical properties associated with wide intercellular clefts in rabbit Purkinje fibres". Journal of physiology. 1979; 290: 227 (#136896)
213. Kass, R S; Siegelbaum, S A; Tsien, R W. "Three-micro-electrode voltage clamp experiments in calf cardiac Purkinje fibres: is slow inward current adequately measured?". Journal of physiology. 1979; 290: 201 (#136897)
214. Marban, E; Tsien, R W. "Ouabain increases the slow inward calcium current in ventricular muscle of the ferret [proceedings]". Journal of physiology. 1979; 292: 72P (#136895)
215. Siegelbaum, S A; Tsien, R W. "Calcium-activated transient outward current in cardiac Purkinje fibres [proceedings]". Journal of physiology. 1979; 287: 36P (#136899)
216. Tsien, R W; Kass, R S; Weingart, R. "Cellular and subcellular mechanisms of cardiac pacemaker oscillations". Journal of experimental biology. 1979; 81: 205 (#136894)
217. Kass, R S; Lederer, W J; Tsien, R W; Weingart, R. "Role of calcium ions in transient inward currents and aftercontractions induced by strophanthidin in cardiac Purkinje fibres". Journal of physiology. 1978; 281: 187 (#136901)
218. Kass, R S; Tsien, R W; Weingart, R. "Ionic basis of transient inward current induced by strophanthidin in cardiac Purkinje fibres". Journal of physiology. 1978; 281: 209 (#136900)
219. Tsien, R W; Carpenter, D O. "Ionic mechanisms of pacemaker activity in cardiac Purkinje fibers". Federation proceedings (Federation of American Societies for Experimental Biology). 1978; 37: 2127 (#136902)
220. Tsien, R W; Kass, R S; Weingart, R. "Calcium ions and membrane current changes induced by digitals in cardiac Purkinje fibers". Annals of the New York Academy of Sciences. 1978; 307: 483 (#136904)
221. Weingart, R; Kass, R S; Tsien, R W. "Is digitalis inotropy associated with enhanced slow inward calcium current?". Nature. 1978; 273: 389 (#136903)
222. Siegelbaum, S A; Tsien, R W; Kass, R S. "Role of intracellular calcium in the transient outward current of calf Purkinje fibres". Nature. 1977; 269: 611 (#136905)
223. Tsien, R W. "Cyclic AMP and contractile activity in heart". Advances in cyclic nucleotide research. 1977; 8: 363 (#136906)
224. Kass, R S; Siegelbaum, S; Tsien, R W. "Incomplete inactivation of the slow inward current in cardiac Purkinje fibres [proceedings]". Journal of physiology. 1976; 263: 127P (#136908)
225. Kass, R S; Tsien, R W. "Control of action potential duration by calcium ions in cardiac Purkinje fibers". Journal of general physiology. 1976; 67: 599 (#136910)
226. Lederer, W J; Tsien, R W. "Transient inward current underlying arrhythmogenic effects of cardiotonic steroids in Purkinje fibres". Journal of physiology. 1976; 263: 73 (#136907)
227. Tsien, R W. "Possible effects of hydrogen ions in ischemic myocardium". Circulation. 1976; 53: I14 (#136911)
228. Tsien, R W; Weingart, R. "Inotropic effect of cyclic AMP in calf ventricular muscle studied by a cut end method". Journal of physiology. 1976; 260: 117 (#136909)
229. Giles, W; Tsien, R W. "Effects of acetylcholine on membrane currents in frog artrial muscle". Journal of physiology. 1975; 246: 64P (#136915)
230. Kass, R S; Tsien, R W. "Multiple effects of calcium antagonists on plateau currents in cardiac Purkinje fibers". Journal of general physiology. 1975; 66: 169 (#136913)
231. Lederer, W J; Tsien, R W. "Proceedings: Transient inward current underlying strophanthidin's enhancement of pace-maker activity in Purkinje fibres". Journal of physiology. 1975; 249: 40P (#136914)
232. McAllister, R E; Noble, D; Tsien, R W. "Reconstruction of the electrical activity of cardiac Purkinje fibres". Journal of physiology. 1975; 251: 1 (#136912)
233. Tsien, R W. "Effects of epinephrine on the pacemaker potassium current of cardiac Purkinje fibers". Journal of general physiology. 1974; 64: 293 (#136917)
234. Tsien, R W. "Mode of action of chronotropic agents in cardiac Purkinje fibers. Does epinephrine act by directly modifying the external surface charge?". Journal of general physiology. 1974; 64: 320 (#136918)
235. Tsien, R W; Weingart, R. "Proceedings: Cyclic AMP: cell-to-cell movement and inotropic effect in ventricular muscle, studied by a cut-end method". Journal of physiology. 1974; 242: 95P (#136916)
236. Tsien, R W. "Adrenaline-like effects of intracellular iontophoresis of cyclic AMP in cardiac Purkinje fibres". Nature: new biology. 1973; 245: 120 (#136920)
237. Tsien, R W. "Control of conductance in cardiac membrane permeability". Neurosciences research program bulletin. 1973; 11: 204 (#136921)
238. Tsien, R W. "Proceedings: Does adrenaline act by directly modifying the external membrane surface charge of cardiac Purkinje fibres?". Journal of physiology. 1973; 234: 37P (#136919)
239. Hauswirth, O; Noble, D; Tsien, R W. "Separation of the pace-maker and plateau components of delayed rectification in cardiac Purkinje fibres". Journal of physiology. 1972; 225: 211 (#136923)
240. Hausworth, O; Noble, D; Tsien, R W. "The dependence of plateau currents in cardiac Purkinje fibres on the interval between action potentials". Journal of physiology. 1972; 222: 27 (#136924)
241. Tsien, R W; Giles, W; Greengard, P. "Cyclic AMP mediates the effects of adrenaline on cardiac purkinje fibres". Nature: new biology. 1972; 240: 181 (#136922)
242. Hauswirth, O; McAllister, R E; Noble, D; Tsien, R W. "Reconstruction of the actions of adrenaline and calcium on cardiac pacemaker potentials". Journal of physiology. 1969; 204: 126P+ (#136925)
243. Hauswirth, O; Noble, D; Tsien, R W. "The mechanism of oscillatory activity at low membrane potentials in cardiac Purkinje fibres". Journal of physiology. 1969; 200: 255 (#136926)
244. Noble, D; Tsien, R W. "Outward membrane currents activated in the plateau range of potentials in cardiac Purkinje fibres". Journal of physiology. 1969; 200: 205 (#136928)
245. Noble, D; Tsien, R W. "Reconstruction of the repolarization process in cardiac Purkinje fibres based on voltage clamp measurements of membrane current". Journal of physiology. 1969; 200: 233 (#136927)
246. Hauswirth, O; Noble, D; Tsien, R W. "Adrenaline: mechanism of action on the pacemaker potential in cardiac Purkinje fibers". Science. 1968; 162: 916 (#136929)
247. Noble, D; Tsien, R W. "Kinetics of slow component of potassium current in cardiac purkinje fibres". Journal of physiology. 1968; 194: 31P (#136931)
248. Noble, D; Tsien, R W. "The kinetics and rectifier properties of the slow potassium current in cardiac Purkinje fibres". Journal of physiology. 1968; 195: 185 (#136930)

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