Samuel Cohen

Samuel Cohen




MD-PhD Student

Education and Training

  • B.A. in Molecular Biology & Biochemistry, Wesleyan University, 2010

Research Interests

Neuronal activity induces molecular and genetic mechanisms which underlie synaptic plasticity and the establishment and maintenance of functional neural networks. Calcium signaling to the nucleus, through activation of both NMDA Receptors and voltage gated calcium channels, is critical for these long lasting changes. My research focuses on understanding how information from neuronal activity is conveyed to the nucleus by calcium dependent pathways. This will shed light on how neural networks develop, and how they are perturbed in neuropsychiatric disease.

Selected Publications

  • Cohen SM, Ma H, Kuchibhotla KV, Watson BO, Buzsáki G, Froemke RC, Tsien, RW. Excitation-transcription coupling in parvalbumin-positive interneurons employs a novel CaM Kinase-dependent pathway distinct from excitatory neurons. Neuron. 2016. In Press.
  • Cohen SM, Li B, Tsien RW, Ma H. Evolutionary and Functional Perspectives on Signaling from Neuronal Surface to Nucleus.  Biochem Biophys Res Commun. 2015 Apr 24;460(1):88-99 PMID: 25998737
  • Cohen SM, Tsien RW, Goff DC, Halassa MM. The impact of NMDA Receptor hypofunction on GABAergic interneurons in the pathophysiology of schizophrenia. Schizophrenia Research. 2015 Sep;167(1-3):98-107 PMID: 25583246
  • Ma H, Groth RD, Cohen SM, Emery JF, Li B, Hoedt E, Zhang G, Neubert TA, Tsien RW. γCaMKII shuttles Ca2+/CaM to the nucleus to trigger CREB phosphorylation and gene expression. Cell. 159(2):281-94. 2014 Oct 9. PMID: 25303525 PMCID: PMC4201038
  • Witt RM, Hecht ML, Pazyra-Murphy MF, Cohen SM, Noti C, van Kuppevelt TH, Fuller M, Chan JA, Hopwood JJ, Seeberger PH, Segal RA. Heparan sulfate proteoglycans containing a Glypican 5 core and 2-O-Sulfo-Iduronic Acid function as Sonic Hedgehog co-receptors to promote proliferation. The Journal of Biological Chemistry. 288(36):26275-26288. 2013 Jul 18. PMID: 23867465, PMCID: PMC3764831.
  • Ma H, Cohen S, Li B, Tsien RW. Exploring the dominant role of Cav1 channels in signalling to the nucleus. Biosci Rep. 33(1):97-101. 2012 Dec 20. PMID: 23088728, PMCID: PMC3546354.