Richard Tsien, D. Phil.

Richard Tsien, D. Phil.

Director

Email

richard.tsien@nyumc.org

Position

Chair, Department of Physiology and Neuroscience

Selected Publications

  • Kim J, Tsien RW (2008). Synapse-specific adaptations to inactivity in hippocampal circuits achieve homeostatic gain control while dampening network reverberation. Neuron 58(6):925-37.
  • Zhang Q, Li Y, Tsien RW (2009). The dynamic control of kiss-and-run and vesicular reuse probed with single nanoparticles. Science. 2009; 323(5920):1448-53. 
  • Lindskog M, Li L, Groth RD, Poburko D, Thiagarajan TC, Han X, Tsien RW (2010). Postsynaptic GluA1 enables acute retrograde enhancement of presynaptic function to coordinate the adaptation to synaptic inactivity. Proc Natl Acad Sci USA 2010;107(50):21806-11.
  • Groth RD, Lindskog M, Thiagarajan TC, Li L, Tsien RW (2011). Beta Ca2+/CaM-dependent kinase type II triggers upregulation of GluA1 to coordinate adaptation to synaptic inactivity in hippocampal neurons. Proc Natl Acad Sci USA 2011;108(2):838-33.
  • Yoo AS, Sun AX, Li L, Shcheglovitov A, Portmann T, Li Y, Lee-Messer C, Dolmetsch RE, Tsien RW, Crabtree GR (2011). MicroRNA-mediated conversion of human fibroblasts to neurons. Nature 2011;476(7359):228-31.
  • Bader, PL, Faizi M, Kim LH, Owen SF, Tadross MR, Alfa RW, Bett GCL, Tsien RW, Rasmusson RL, Shamloo M (2011). Mouse model of Timothy syndrome recapitulates triad of autistic traits. PNAS 2011;108(37):15432-15437.
  • Mitra A, Mitra S, Tsien RW (2011). Heterogeneous reallocation of presynaptic efficacy in recurrent excitatory microcircuits adapting to inactivity. Nat Neurosci 2011;15(2):250-7.
  • Park H, Li Y, Tsien RW (2012). Influence of synaptic vesicle position on release probability and exocytotic fusion model. Science 2012;335(6074):1362-6.
  • Wheeler DG, Groth RD, Ma H, Barrett CF, Owen SF, Safa P, Tsien RW (2012). CaV1 and CaV2 channels engage distinct modes of Ca2+ signaling to control CREB-dependent gene expression. Cell 2012;149(5):1112-24.
  • Li Y, Tsien RW (2012). pHTomato, a red, genetically encoded indicator that enables multiplex interrogation of synaptic activity. Nat Neurosci 2012;15(7):1047-53.
  • Alabi, A.A., Tsien, RW (2012). Synaptic Vesicle Pools and Dynamics. In: The Synapse, Sheng M, Sabatini BL, Südhof T, eds., Cold Spring Harbor Press, New York. 2012

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Education and Training

  • Research student in Eaton Peabody Laboratory, Massachusetts Eye & Ear Infirmary, Summer, 1966
  • Weir Junior Research Fellow, University College, Oxford, October 1968 - June 1970
  • Lecturing Fellow, Balliol College, Oxford, October 1969 - June 1970
  • Assistant Professor, Department of Physiology, Yale University School of Medicine, June 1970 - June 1974
  • Associate Professor, Department of Physiology, Yale University School of Medicine, July 1974 - June 1979
  • Professor, Department of Physiology, Yale University School of Medicine, July 1979 - July 1988
  • Founder and Chairman, Department of Molecular and Cellular Physiology, Stanford University, August 1988 - August, 1994
  • Director, Silvio Conte - National Institutes of Mental Health Center for Neuroscience Research, Stanford University, 1991- 2001
  • Co-Director, Neurosciences Institute at Stanford, Stanford University, 2000- 2005
  • George D. Smith Professorship in Molecular and Genetic Medicine, Department of Molecular and Cellular Physiology, Stanford University, August 1988 – Dec 2011
  • Druckenmiller Professor of Neuroscience, New York University School of Medicine, August 2011-present
  • Director, NYU Neuroscience Institute, NYU Langone Medical Center, August 2011-present
  • Chair, Department of Physiology and Neuroscience, New York University School of Medicine, January 2012-present
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