Guoling Tian

Guoling Tian

Research Assistant Professor and Lab Manager

Email

Guoling.Tian@nyumc.org

Position

Research Assistant Professor and Lab Manager

Education and Training

  • B.S. in Biochemistry, Department of Biology, East China Normal University, 1984
  • M.S. in Microbiology and Molecular Biology, Department of Microbiology, New York University Medical Center, 1991
  • Ph.D. in Microbiology and Molecular Biology, Department of Microbiology, New York University Medical Center, 1993
  • Postdoctoral Fellow and Assistant Research Scientist, Dept. of Biochemistry, New York University Medical Center, 1993-1999
  • Senior Scientist II/Lab Head, Dept. Functional Genomics, Novartis Pharmaceutical Corp., 1999-2003
  • Research Assistant Professor, Dept. of Biochemistry and Molecular Biology, New York University Medical Center, 2003-2016
  • Research Assistant Professor and RW Tsien Lab Manager, Dept. of Neuroscience, New York University Medical Center, 2016-

Selected Publications

  • Tian G, Vainberg IE, Tap WD, Lewis SA, Cowan NJ. Specificity in chaperonin-mediated protein folding. Nature. 1995 May 18;375(6528):250-3.
  • Tian G, Huang Y, Rommelaere H, Vandekerckhove J, Ampe C, Cowan NJ.  Pathway leading to correctly folded beta-tubulin. Cell. 1996 Jul 26;86(2):287-96.
  • Tian G, Huang MC, Parvari R, Diaz GA, Cowan NJ. Cryptic out-of-frame translational initiation of TBCE rescues tubulin formation in compound heterozygous HRD. Proc Natl Acad Sci U S A. 2006 Sep 5;103(36):13491-6.
  • Keays DA, Tian G, Poirier K, Huang GJ, Siebold C, Cleak J, Oliver PL, Fray M, Harvey RJ, Molnár Z, Piñon MC, Dear N, Valdar W, Brown SD, Davies KE, Rawlins JN, Cowan NJ, Nolan P, Chelly J, Flint J. 2007. Mutations in alpha-tubulin cause abnormal neuronal migration in mice and lissencephaly in humans. Cell 128(1):45-57.
  • Tian G, Jaglin XH, Keays DA, Francis F, Chelly J, Cowan NJ. 2010. Disease-associated mutations in TUBA1A result in a spectrum of defects in the tubulin folding and heterodimer assembly pathway. Hum Mol Genet. 19(18):3599-613.
  • Tian G, Cowan NJ. Tubulin-specific chaperones: components of a molecular machine that assembles the α/β heterodimer. 2013. Methods Cell Biol. 115:155-71.
  • Poirier K, Lebrun N, Broix L, Tian G, Saillour Y, Boscheron C, Parrini E, Valence S, Pierre BS, Oger M, Lacombe D, Geneviève D, Fontana E, Darra F, Cances C, Barth M, Bonneau D, Bernadina BD, N'guyen S, Gitiaux C, Parent P, des Portes V, Pedespan JM, Legrez V, Castelnau-Ptakine L, Nitschke P, Hieu T, Masson C, Zelenika D, Andrieux A, Francis F, Guerrini R, Cowan NJ, Bahi-Buisson N, Chelly J.  Mutations in TUBG1, DYNC1H1, KIF5C and KIF2A cause malformations of cortical development and microcephaly. Nat Genet. 2013 Jun;45(6):639-47.
  • Feng R, Sang Q, Kuang Y, Sun X, Yan Z, Zhang S, Shi J, Tian G, Luchniak A, Fukuda Y, Li B, Yu M, Chen J, Xu Y, Guo L, Qu R, Wang X, Sun Z, Liu M, Shi H, Wang H, Feng Y, Shao R, Chai R, Li Q, Xing Q, Zhang R, Nogales E, Jin L, He L, Gupta ML Jr, Cowan NJ, Wang L. Mutations in TUBB8 and Human Oocyte Meiotic Arrest. N Engl J Med. 2016 Jan 21;374(3):223-32.
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