Boxing Li

Boxing Li

Post-Doctoral Fellow



Post-Doctoral Fellow

Education and Training

  • Bachelor in Clinical Medicine, The First Military Medical University, Guangzhou, China, 1998-2003
  • Master in Medicine, The First Military Medical University, Guangzhou, China, 2003-2006
  • Ph.D. in Neurobiology, Southern Medical University, Guangzhou, China, 2006-2009
  • Teaching Asistant, Department of Neurobiology, Southern Medical University, Guangzhou, China., 2006-2009
  • Lecturer, Department of Neurobiology, Southern Medical University, Guangzhou, China., 2009-2012
  • Post-Doctoral Fellow, Department of Physiology and Neuroscience, New York University School of Medicine, New York, 2012-present

Research Interests

  • Calcium signaling abnormalities in neuropsychiatric disorders
  • Calcium signaling in homeostatic plasticity
  • Subcellular ion channel function

Selected Publications

  • Boxing Li*, Michael Tadross*, Richard W. Tsien. Sequential ionic and conformational signaling by calcium channels drives neuronal gene expression. Science. 2016, 351(6275):863-86. (* - equal contribution)
  • Boxing Li, Wei Hie, Lianyan Huang, Peng Wei, Shuji Li, Zhengyi Luo, Allyson K. Friedman, Andrea L. Meredith, Ming-Hu Han, Xin-Hong Zhu, Tian-Ming Gao*. Nuclear BK channels regulate gene expression via the control of nuclear calcium signaling. Nature Neuroscience. 2014, 17(8):1055-63.
  • Lianyan Huang*, Boxing Li*, Shihao Tang, Hongbo Guo, Wenjun Li, Xiaozhou Huang, Wenjuan Yan, Fei Zou*. Mitochondrial KATP Channels Control Glioma Radioresistance by Regulating ROS-Induced ERK Activation. Molecular Neurobiology. 2015, 52(1):626-37. (* - equal contribution)
  • Lianyan Huang*, Boxing Li*, Wenjun Li, Hongbo Guo Fei Zou. ATP-sensitive potassium channels control glioma cells proliferation by regulating ERK activity Carcinogenesis 2009, 30(5):737–744. (* - equal contribution)
  • Huan Ma, Rachel Groth, Samuel Cohen, John Emery, Boxing Li, Esthelle Hoedt, Guoan Zhang,Thomas Neubert, Richard Tsien. γCaMKII shuttles Ca2+/CaM to the nucleus to trigger CREB phosphorylation and gene expression. Cell. 2014, 159: 281–294 (Highlighted in Preview by Johannes Hell, Cell 159: 235–237)
  • Huan Ma, Boxing Li, Richard Tsien. Distinct roles of multiple isoforms of CaMKII in signaling to the nucleus. Biochim Biophys Acta. 2015 Feb 17. pii: S0167-4889(15).
  • Samuel Cohen, Boxing Li, Richard Tsien, Huan Ma. Evolutionary and functional perspectives on signaling from neuronal surface to nucleus. Biochem Biophys Res Commun. 2015 24; 460 (1):88-99.
  • Huan Ma, Samuel Cohen, Boxing Li and Richard W. Tsien. Exploring the dominant role of Cav1 channels in signalling to the nucleus. Biosci Rep. 2012, 33(1):97-101.
  • Ming Chen, Hongyu Sun, Ping Hu, Chunfei Wang, Boxing Li, Shuji Li, Jianjun Li, Huiying Tan, Tian-Ming Gao. Activation of BKca channels mediates hippocampal neuronal death after reoxygenation and reperfusion. Molecular Neurobiology. 2013, 48(3):794-807.
  • Zhao ST, Chen M, Li SJ, Zhang MH, Boxing Li, Das M, Bean JC, Kong JM, Zhu XH, Gao TM Mitochondrial BNIP3 upregulation precedes endonuclease G translocation in hippocampal neuronal death following oxygen-glucose deprivation. BMC Neurosci. 2009, 10:113.
  • Lianyan Huang, Wenjun Li, Boxing Li, Fei Zou. Activation of ATP-sensitive K channels protects hippocampal CA1 neurons from hypoxia by suppressing p53 expression. Neuroscience Letters 2006, 398:34–38.

Book Chapters

  • Boxing Li, Tian-Ming Gao. Functional Role of Mitochondrial and Nuclear BK channels. In: Big on Bk: Current Insights into the Function of Large Conductance Voltage- and Ca2+- Activated K+ Channels at the Molecular, Cellular and Systemic Levels. International Review of Neurobiology. 2016
  • Ming Chen, Boxing Li, Tian-Ming Gao. Novel Neuroprotective Strategy for Stroke­—Activating Inherent Neuronal Survival Mechanisms. In: Pathways to Cures: Neurodegenerative Diseases in China. S. Sanders, Z. Zhang, B. Tang, Eds. Science/AAAS, Washington DC, 2013, pp.62-64.